abstract：:Targeting of steroidogenic enzymes (e.g., abiraterone acetate targeting CYP17A1) has been developed as a novel therapeutic strategy against metastatic castration-resistant prostate cancer (CRPC). However, resistance to steroidal inhibitors inevitably develops in patients, the mechanisms of which remain largely unknown...

journal_title：Cancer research

authors： Xiao L,Wang Y,Xu K,Hu H,Xu Z,Wu D,Wang Z,You W,Ng CF,Yu S,Chan FL

更新日期：2018-05-01 00:00:00

abstract：:Metabolic reprogramming is a hallmark of cancer that includes increased glucose uptake and accelerated aerobic glycolysis. This phenotype is required to fulfill anabolic demands associated with aberrant cell proliferation and is often mediated by oncogenic drivers such as activated BRAF. In this study, we show that th...

journal_title：Cancer research

authors： Houles T,Gravel SP,Lavoie G,Shin S,Savall M,Méant A,Grondin B,Gaboury L,Yoon SO,St-Pierre J,Roux PP

更新日期：2018-05-01 00:00:00

abstract：:Tumor metabolism is reprogrammed to meet the demands of proliferating cancer cells. In particular, cancer cells upregulate synthesis of the membrane phospholipids phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdE) in order to allow for rapid membrane turnover. Nonetheless, we show here that, in mutant is...

journal_title：Cancer research

authors： Viswanath P,Radoul M,Izquierdo-Garcia JL,Ong WQ,Luchman HA,Cairncross JG,Huang B,Pieper RO,Phillips JJ,Ronen SM

更新日期：2018-05-01 00:00:00

abstract：:Highly glycolytic cervical cancers largely resist treatment by cisplatin and coadministered pelvic irradiation as the present standard of care. In this study, we investigated the effects of inhibiting glycolysis and thiol redox metabolism to evaluate them as alternate treatment strategies in these cancers. In a panel ...

journal_title：Cancer research

authors： Rashmi R,Huang X,Floberg JM,Elhammali AE,McCormick ML,Patti GJ,Spitz DR,Schwarz JK

更新日期：2018-03-15 00:00:00

abstract：:Inflammasomes are key regulators of innate immunity in chronic inflammatory disorders and autoimmune diseases, but their role in inflammation-associated tumorigenesis remains ill-defined. Here we reveal a protumorigenic role in gastric cancer for the key inflammasome adaptor apoptosis-related speck-like protein contai...

journal_title：Cancer research

authors： Deswaerte V,Nguyen P,West A,Browning AF,Yu L,Ruwanpura SM,Balic J,Livis T,Girard C,Preaudet A,Oshima H,Fung KY,Tye H,Najdovska M,Ernst M,Oshima M,Gabay C,Putoczki T,Jenkins BJ

更新日期：2018-03-01 00:00:00

abstract：:Deleterious mutations of the ubiquitin carboxy-terminal hydrolase BAP1 found in cancers are predicted to encode inactive truncated proteins, suggesting that loss of enzyme function is a primary tumorigenic mechanism. However, many tumors exhibit missense mutations or in-frame deletions or insertions, often outside the...

journal_title：Cancer research

authors： Peng H,Prokop J,Karar J,Park K,Cao L,Harbour JW,Bowcock AM,Malkowicz SB,Cheung M,Testa JR,Rauscher FJ 3rd

更新日期：2018-03-01 00:00:00

abstract：:Chimeric antigen receptor (CAR) T-cell therapy is an emerging immunotherapy against several malignancies including glioblastoma, the most common and most aggressive malignant primary brain tumor in adults. The challenges in solid tumor immunotherapy comprise heterogenously expressed tumor target antigens and restricte...

journal_title：Cancer research

authors： Weiss T,Weller M,Guckenberger M,Sentman CL,Roth P

更新日期：2018-02-15 00:00:00

abstract：:Cancer stem-like cells (CSC) in hepatocellular carcinoma (HCC) are thought to mediate therapeutic resistance and poor survival outcomes, but their intrinsic and extrinsic control is not well understood. In this study, we found that the chromatin modification factor LSD1 is highly expressed in HCC CSC where it decrease...

journal_title：Cancer research

authors： Liu C,Liu L,Chen X,Cheng J,Zhang H,Zhang C,Shan J,Shen J,Qian C

更新日期：2018-02-15 00:00:00

abstract：:DNA methylation aberrations have been implicated in acquired resistance to platinum drugs in ovarian cancer. In this study, we elucidated an epigenetic signature associated with platinum drug resensitization that may offer utility in predicting the outcomes of patients who are coadministered a DNA methyltransferase in...

journal_title：Cancer research

authors： Fang F,Cardenas H,Huang H,Jiang G,Perkins SM,Zhang C,Keer HN,Liu Y,Nephew KP,Matei D

更新日期：2018-02-01 00:00:00

abstract：:Fatigue is the most common symptom of cancer at diagnosis, yet causes and effective treatments remain elusive. As tumors can be highly inflammatory, it is generally accepted that inflammation mediates cancer-related fatigue. However, evidence to support this assertion is mostly correlational. In this study, we directl...

journal_title：Cancer research

authors： Grossberg AJ,Vichaya EG,Christian DL,Molkentine JM,Vermeer DW,Gross PS,Vermeer PD,Lee JH,Dantzer R

更新日期：2018-02-01 00:00:00

abstract：:Ubiquitination and ubiquitin-like posttranslational modifications (PTM) regulate activity and stability of oncoproteins and tumor suppressors. This implicates PTMs as antineoplastic targets. One way to alter PTMs is to inhibit activity of deubiquitinases (DUB) that remove ubiquitin or ubiquitin-like proteins from subs...

journal_title：Cancer research

authors： Mustachio LM,Lu Y,Kawakami M,Roszik J,Freemantle SJ,Liu X,Dmitrovsky E

更新日期：2018-02-01 00:00:00

abstract：:The nuclear receptor PPAR-β/δ (PPARD) has essential roles in fatty acid catabolism and energy homeostasis as well as cell differentiation, inflammation, and metabolism. However, its contributions to tumorigenesis are uncertain and have been disputed. Here, we provide evidence of tumor suppressive activity of PPARD in ...

journal_title：Cancer research

authors： Martín-Martín N,Zabala-Letona A,Fernández-Ruiz S,Arreal L,Camacho L,Castillo-Martin M,Cortazar AR,Torrano V,Astobiza I,Zúñiga-García P,Ugalde-Olano A,Loizaga-Iriarte A,Unda M,Valcárcel-Jiménez L,Arruabarrena-Aristorena A,Pi

更新日期：2018-01-15 00:00:00

abstract：:Two opposing clusters of transcription factors (TF) have been associated with the differential risks of estrogen receptor positive or negative breast cancers, but the mechanisms underlying the opposing functions of the two clusters are undefined. In this study, we identified NFIB and YBX1 as novel interactors of the e...

journal_title：Cancer research

authors： Campbell TM,Castro MAA,de Oliveira KG,Ponder BAJ,Meyer KB

更新日期：2018-01-15 00:00:00

abstract：:CTLA4 is a cell surface receptor on T cells that functions as an immune checkpoint molecule to enforce tolerance to cognate antigens. Anti-CTLA4 immunotherapy is highly effective at reactivating T-cell responses against melanoma, which is postulated to be due to targeting CTLA4 on T cells. Here, we report that CTLA4 i...

journal_title：Cancer research

authors： Mo X,Zhang H,Preston S,Martin K,Zhou B,Vadalia N,Gamero AM,Soboloff J,Tempera I,Zaidi MR

更新日期：2018-01-15 00:00:00

abstract：:Preclinical and clinical development of agents that inhibit cell-cycle progression have brought an understanding of the feasibility of targeting various cell-cycle regulators in patients with cancer. Small molecule inhibitors targeting key proteins that participate in cell-cycle progression including the cyclin-depend...

journal_title：Cancer research

authors： Mills CC,Kolb EA,Sampson VB

更新日期：2018-01-15 00:00:00

abstract：:The major transmission route for Kaposi sarcoma-associated herpesvirus (KSHV) infection is the oral cavity through saliva. Kaposi sarcoma (KS) frequently occurs in the oral cavity in HIV-positive individuals and is often the first presenting sign of AIDS. However, the oral target cells for KSHV infection and the cellu...

journal_title：Cancer research

authors： Li Y,Zhong C,Liu D,Yu W,Chen W,Wang Y,Shi S,Yuan Y

更新日期：2018-01-01 00:00:00

abstract：:The complement cascade is a part of the innate immune system that acts primarily to remove pathogens and injured cells. However, complement activation is also peculiarly associated with tumor progression. Here we report mechanistic insights into this association in multiple immunocompetent orthotopic models of lung ca...

journal_title：Cancer research

authors： Kwak JW,Laskowski J,Li HY,McSharry MV,Sippel TR,Bullock BL,Johnson AM,Poczobutt JM,Neuwelt AJ,Malkoski SP,Weiser-Evans MC,Lambris JD,Clambey ET,Thurman JM,Nemenoff RA

更新日期：2018-01-01 00:00:00

abstract：:Recent genomic studies have identified subtypes of uterine leiomyoma (LM) with distinctive genetic alterations. Here, we report the elucidation of the biological characteristics of the two most prevalent uterine leiomyoma subtypes, MED12-mutant (MED12-LM) and HMGA2-overexpressing (HMGA2-LM) uterine leiomyomas. Because...

journal_title：Cancer research

authors： Wu X,Serna VA,Thomas J,Qiang W,Blumenfeld ML,Kurita T

更新日期：2017-12-15 00:00:00

abstract：:Inhibition of PACE4, a proprotein convertase that is overexpressed in prostate cancer, has been shown to block cancer progression in an androgen-independent manner. However, the basis for its overexpression and its growth-inhibitory effects are mitigated and uncertain. Here, we report that PACE4 pre-mRNA undergoes DNA...

journal_title：Cancer research

authors： Couture F,Sabbagh R,Kwiatkowska A,Desjardins R,Guay SP,Bouchard L,Day R

更新日期：2017-12-15 00:00:00

abstract：:Although dietary calcium intake has long been recommended for disease prevention, the influence of calcium in development of cancer in the upper gastrointestinal tract has not been explored. Here, we assess the roles of calcium and calcium-sensing receptor (CaSR) in gastric cancer development. CaSR expression was enha...

journal_title：Cancer research

authors： Xie R,Xu J,Xiao Y,Wu J,Wan H,Tang B,Liu J,Fan Y,Wang S,Wu Y,Dong TX,Zhu MX,Carethers JM,Dong H,Yang S

更新日期：2017-12-01 00:00:00

abstract：:Astrocytes, the most abundant type of glial cells in the brain, play critical roles in supporting neuronal development and brain function. Although astrocytes have been frequently detected in brain tumors, including medulloblastoma (MB), their functions in tumorigenesis are not clear. Here, we demonstrate that astrocy...

journal_title：Cancer research

authors： Liu Y,Yuelling LW,Wang Y,Du F,Gordon RE,O'Brien JA,Ng JMY,Robins S,Lee EH,Liu H,Curran T,Yang ZJ

更新日期：2017-12-01 00:00:00

abstract：:Despite the fact that the local immunological microenvironment shapes the prognosis of colorectal cancer, immunotherapy has shown no benefit for the vast majority of colorectal cancer patients. A better understanding of the complex immunological interplay within the microenvironment is required. In this study, we util...

journal_title：Cancer research

authors： Kather JN,Poleszczuk J,Suarez-Carmona M,Krisam J,Charoentong P,Valous NA,Weis CA,Tavernar L,Leiss F,Herpel E,Klupp F,Ulrich A,Schneider M,Marx A,Jäger D,Halama N

更新日期：2017-11-15 00:00:00

abstract：:Alterations in mitochondrial DNA (mtDNA) were once thought to be predominantly innocuous to cell growth. Recent evidence suggests that mtDNA undergo naturally occurring alterations, including mutations and polymorphisms, which profoundly affect the cells in which they appear and contribute to a variety of diseases, in...

journal_title：Cancer research

authors： Bussard KM,Siracusa LD

更新日期：2017-11-15 00:00:00

abstract：:MTH1 helps prevent misincorporation of ROS-damaged dNTPs into genomic DNA; however, there is little understanding of how MTH1 itself is regulated. Here, we report that MTH1 is regulated by polyubiquitination mediated by the E3 ligase Skp2. In melanoma cells, MTH1 was upregulated commonly mainly due to its improved sta...

journal_title：Cancer research

authors： Wang JY,Liu GZ,Wilmott JS,La T,Feng YC,Yari H,Yan XG,Thorne RF,Scolyer RA,Zhang XD,Jin L

更新日期：2017-11-15 00:00:00

abstract：:Genotoxicity-induced hair loss from chemotherapy and radiotherapy is often encountered in cancer treatment, and there is a lack of effective treatment. In growing hair follicles (HF), quiescent stem cells (SC) are maintained in the bulge region, and hair bulbs at the base contain rapidly dividing, yet genotoxicity-sen...

journal_title：Cancer research

authors： Huang WY,Lai SF,Chiu HY,Chang M,Plikus MV,Chan CC,Chen YT,Tsao PN,Yang TL,Lee HS,Chi P,Lin SJ

更新日期：2017-11-15 00:00:00

abstract：:The NCI Genomic Data Commons (GDC) was launched in 2016 and makes available over 4 petabytes (PB) of cancer genomic and associated clinical data to the research community. This dataset continues to grow and currently includes over 14,500 patients. The GDC is an example of a biomedical data commons, which collocates bi...

journal_title：Cancer research

authors： Wilson S,Fitzsimons M,Ferguson M,Heath A,Jensen M,Miller J,Murphy MW,Porter J,Sahni H,Staudt L,Tang Y,Wang Z,Yu C,Zhang J,Ferretti V,Grossman RL,GDC Project.

更新日期：2017-11-01 00:00:00

abstract：:Molecular docking is a standard computational approach to predict binding modes of protein-ligand complexes by exploring alternative orientations and conformations of the ligand (i.e., by exploring ligand flexibility). Docking tools are largely used for virtual screening of small drug-like molecules, but their accurac...

journal_title：Cancer research

authors： Antunes DA,Moll M,Devaurs D,Jackson KR,Lizée G,Kavraki LE

更新日期：2017-11-01 00:00:00

abstract：:Diffusion MRI (dMRI) is the only noninvasive method for mapping white matter connections in the brain. We describe SlicerDMRI, a software suite that enables visualization and analysis of dMRI for neuroscientific studies and patient-specific anatomic assessment. SlicerDMRI has been successfully applied in multiple stud...

journal_title：Cancer research

authors： Norton I,Essayed W,Zhang F,Pujol S,Yarmarkovich A,Golby AJ,Kindlmann G,Wassermann D,Estepar RSJ,Rathi Y,Pieper S,Kikinis R,Johnson HJ,Westin CF,O'Donnell LJ

更新日期：2017-11-01 00:00:00

abstract：:The lipid hydrolase enzyme acid sphingomyelinase (ASM) is required for the conversion of the lipid cell membrane component sphingomyelin into ceramide. In cancer cells, ASM-mediated ceramide production is important for apoptosis, cell proliferation, and immune modulation, highlighting ASM as a potential multimodal the...

journal_title：Cancer research

authors： Kachler K,Bailer M,Heim L,Schumacher F,Reichel M,Holzinger CD,Trump S,Mittler S,Monti J,Trufa DI,Rieker RJ,Hartmann A,Sirbu H,Kleuser B,Kornhuber J,Finotto S

更新日期：2017-11-01 00:00:00

abstract：:Expression of the ectonucleotidase CD73 by tumor cells, stromal cells, and immune cells is associated in cancer with immune suppression. In this study, we investigated the role of CD73 on the activity of the anti-HER2/ErbB2 monoclonal antibody (mAb) trastuzumab. In a prospective, randomized phase III clinical trial ev...

journal_title：Cancer research

authors： Turcotte M,Allard D,Mittal D,Bareche Y,Buisseret L,José V,Pommey S,Delisle V,Loi S,Joensuu H,Kellokumpu-Lehtinen PL,Sotiriou C,Smyth MJ,Stagg J

更新日期：2017-10-15 00:00:00

abstract：:Lymphangioleiomyomatosis (LAM) is a progressive destructive neoplasm of the lung associated with inactivating mutations in the TSC1 or TSC2 tumor suppressor genes. Cell or animal models that accurately reflect the pathology of LAM have been challenging to develop. Here, we generated a robust human cell model of LAM by...

journal_title：Cancer research

authors： Julian LM,Delaney SP,Wang Y,Goldberg AA,Doré C,Yockell-Lelièvre J,Tam RY,Giannikou K,McMurray F,Shoichet MS,Harper ME,Henske EP,Kwiatkowski DJ,Darling TN,Moss J,Kristof AS,Stanford WL

更新日期：2017-10-15 00:00:00

abstract：:Immunity to infectious agents involves a coordinated response of innate and adaptive immune cells working in concert, with many feed-forward and regulatory interactions between both arms of the immune system. In contrast, many therapeutic strategies to augment immunity against tumors have focused predominantly on stim...

journal_title：Cancer research

authors： Moynihan KD,Irvine DJ

更新日期：2017-10-01 00:00:00

abstract：:Triple-negative breast cancers (TNBC) are highly aggressive, lack FDA-approved targeted therapies, and frequently recur, making the discovery of novel therapeutic targets for this disease imperative. Our previous analysis of the molecular mechanisms of action of bromodomain and extraterminal protein inhibitors (BETi) ...

journal_title：Cancer research

authors： Sahni JM,Gayle SS,Webb BM,Weber-Bonk KL,Seachrist DD,Singh S,Sizemore ST,Restrepo NA,Bebek G,Scacheri PC,Varadan V,Summers MK,Keri RA

更新日期：2017-10-01 00:00:00

abstract：:Cells lacking the tumor suppressor gene LKB1/STK11 alter their metabolism to match the demands of accelerated growth, leaving them highly vulnerable to stress. However, targeted therapy for LKB1-deficient cancers has yet to be reported. In both Kras/p53/Lkb1 cell lines and a genetically engineered mouse model of Kras/...

journal_title：Cancer research

authors： Liu Y,Li Y,Wang X,Liu F,Gao P,Quinn MM,Li F,Merlino AA,Benes C,Liu Q,Gray NS,Wong KK

更新日期：2017-09-15 00:00:00

abstract：:Interplay between tumor cells and host cells in the tumor microenvironment dictates the development of all cancers. In breast cancer, malignant cells educate host macrophages to adopt a protumorigenic phenotype. In this study, we show how the integrin-regulatory protein kindlin-2 (FERMT2) promotes metastatic progressi...

journal_title：Cancer research

authors： Sossey-Alaoui K,Pluskota E,Bialkowska K,Szpak D,Parker Y,Morrison CD,Lindner DJ,Schiemann WP,Plow EF

更新日期：2017-09-15 00:00:00

abstract：:The epithelial-to-mesenchymal transition (EMT) is a reversible process comprised of various subprograms via which epithelial cells reduce their intercellular adhesions and proliferative capacity while gaining a mesenchymal phenotype with increased migratory and invasive properties. This process has been well described...

journal_title：Cancer research

authors： Sannino G,Marchetto A,Kirchner T,Grünewald TGP

更新日期：2017-09-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is a molecularly heterogeneous cancer that is difficult to treat. Despite the role it may play in tumor progression and response to therapy, microenvironmental (stromal) heterogeneity in TNBC has not been well characterized. To address this challenge, we investigated the transcript...

journal_title：Cancer research

authors： Saleh SMI,Bertos N,Gruosso T,Gigoux M,Souleimanova M,Zhao H,Omeroglu A,Hallett MT,Park M

更新日期：2017-09-01 00:00:00

abstract：:The apolipoprotein B mRNA editing enzyme catalytic polypeptide-like APOBEC3A and APOBEC3B have emerged as key mutation drivers in cancer. Here, we show that APOBEC3A and APOBEC3B activities impose a unique type of replication stress by inducing abasic sites at replication forks. In contrast to cells under other types ...

journal_title：Cancer research

authors： Buisson R,Lawrence MS,Benes CH,Zou L

更新日期：2017-09-01 00:00:00

abstract：:Therapeutic strategies targeting DNA repair pathway defects have been widely explored, but often only benefit small numbers of patients. Here we characterized potential predictive biomarkers for treatment with AsiDNA, a novel first-in-class DNA repair inhibitor. We evaluated genetic instability and DNA repair defects ...

journal_title：Cancer research

authors： Jdey W,Thierry S,Popova T,Stern MH,Dutreix M

更新日期：2017-08-15 00:00:00

abstract：:T-cell infiltration of solid tumors is associated with improved prognosis and favorable responses to immunotherapy. Mechanisms that enable tumor infiltration of CD8+ T cells have not been defined, nor have drugs that assist this process been discovered. Here we address these issues with a focus on VE-cadherin, a major...

journal_title：Cancer research

authors： Zhao Y,Ting KK,Li J,Cogger VC,Chen J,Johansson-Percival A,Ngiow SF,Holst J,Grau G,Goel S,Muller T,Dejana E,McCaughan G,Smyth MJ,Ganss R,Vadas MA,Gamble JR

更新日期：2017-08-15 00:00:00